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Prior to her joining the cast, in the episode "The Bat Jar Conjecture", Raj suggests recruiting the real-life Bialik to their Physics Bowl team, saying "You know who's apparently very smart is the girl who played TV's Blossom. On August 20, 2019, it was announced that she and her new production company, Sad Clown Productions, had signed exclusive contracts with Warner Bros. Mackenzie Gabriel-Vaught, a former executive at Chuck Lorre Productions, will be head of development for Sad Clown.

The character Amy is a neurobiologist, which is related to Bialik's real-life doctorate in neuroscience.Molloy at first produced six episodes for a tryout run, followed by the shooting of the pilot special for Blossom.The latter actually aired two weeks before Bialik's Fox series and ultimately garnered higher ratings than the former.Old-fashioned romance isnt dead, however: among the surveys...-lik; born December 12, 1975) is an American actress, author, and neuroscientist. For her role as Fowler, Bialik has been nominated four times for the Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series Her dissertation was an investigation of hypothalamic activity in patients with Prader–Willi syndrome, entitled "Hypothalamic regulation in relation to maladaptive, obsessive-compulsive, affiliative and satiety behaviors in Prader–Willi syndrome." and guest appearances on The Facts of Life and Beauty and the Beast.

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